Publications

Hupp S, Foertsch C, Graber F, Mitchell TJ, Iliev AI. 
Pneumolysin boosts the neuroinflammatory response to Streptococcus pneumoniae through enhanced endocytosis. Nat Commun. 2022 Aug 26;13(1):5032.
doi: 10.1038/s41467-022-32624-2.

Hupp S, Tomov NS, Bischoff C, Baronti D, Iliev AI.
Easy to build cost-effective acute brain slice incubation system for parallel analysis of multiple treatment conditions.
J Neurosci Methods. 2022;366:109405. doi: 10.1016/j.jneumeth.2021.109405.

Hupp S., Iliev A.I. (2020)
CSF-1 receptor inhibition as a highly effective tool for depletion of microglia in mixed glial cultures.
J Neurosci Methods, 332:108537. doi: 10.1016/j.jneumeth.2019.108537.

Hupp S., Grandgirard D., Mitchell T.J., Leib S.L., Hathaway L.J., Iliev A.I. (2019)
Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia.
J Neuroinflammation, 16(1):105. doi: 10.1186/s12974-019-1491-7.

Maurer J., Hupp S., Pillich H., Mitchell T.J., Chakraborty T., Iliev A.I. (2018)
Missing elimination via membrane vesicle shedding contributes to diminished calcium sensitivity of listeriolysin O.
Nature Sci Rep, 26;8(1):15846. doi: 10.1038/s41598-018-34031-4.

Seele J., Tauber S.C., Bunkowski S, Baums C.G., Valentin-Weigand P., de Buhr N., Beineke A., Iliev A.I., Brück W., Nau R. (2018)
The inflammatory response and neuronal injury in Streptococcus suis meningitis.
BMC Infect Dis. 18(1):297. doi: 10.1186/s12879-018-3206-6.

Hupp S, Ribes S, Seele J, Wippel C, Förtsch C, Maier E, Ma J, Benz R, Mitchell TJ, Nau R, Iliev A.I. (2017)
Magnesium therapy improves outcome in Streptococcus pneumoniae meningitis by altering pneumolysin pore formation
Br J Pharm, doi: 10.1111/bph.14027

Maurer J, Hupp S, Bischoff C, Foertsch C, Mitchell TJ, Chakraborty T, Iliev A.I. (2017)
Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes.
Toxins, 9(1). pii: E34. doi: 10.3390/toxins9010034.

Wippel C, Maurer J, Förtsch C, Hupp S, Ma J, Mitchell T, Bunkowski S, Brück W, Nau R, Iliev AI.
NMDA-dependent dendritic and synaptic pathology by the cholesterol-dependent cytolysin pneumolysin in bacterial meningitis.
PLoS Pathog.; 9(6):e1003380. doi: 10.1371/journal.ppat.1003380.
2013

Hupp S, Förtsch C, Wippel C, Ma J, Mitchell TJ, Iliev AI.
Direct transmembrane interaction between actin and the pore-competent cholesterol-dependent cytolysin pneumolysin extends the cellular role of pore formation.
J Mol Biol, 425(3):636-46. doi: 10.1016/j.jmb.2012.11.034
2013

Hupp S, Heimeroth V, Wippel C, Förtsch C, Ma J, Mitchell TJ, Iliev AI.
Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema.
Glia, 60(1):137-46. doi: 10.1002/glia.21256.
2012

Wippel C, Förtsch C, Hupp S, Maier E, Benz R, Ma J, Mitchell TJ, Iliev AI.
Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue.
J Infect Dis., 204(6):930-6.
2011

Förtsch C., Hupp S., Ma J., Mitchell T.J., Maier E., Benz R., Iliev A.I. Changes in Astrocyte Shape Induced by Sublytic Concentrations of the Cholesterol-Dependent Cytolysin Pneumolysin Still Require Pore-Forming Capacity.
Toxins; 3(1):43-62.
2011

Iliev A.I., Djannatian J.R., Opazo F., Gerber J., Nau R., Mitchell T.J., Wouters F.S.
Rapid microtubule bundling and stabilization by the Streptococcus pneumoniae neurotoxin pneumolysin in a cholesterol-dependent, non-lytic and Src-kinase dependent manner inhibits intracellular trafficking. Molecular Microbiology, 71, 461-477.
2008

Iliev A.I., Djannatian J.R., Nau R., Mitchell T.J., Wouters F.S. Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin. 
Proc. Natl. Acad. Sci. U S A, 104(8):2897-902.
2007

Iliev A.I., Wouters F.S.
Application of simple photobleaching microscopy techniques for the determination of the balance between anterograde and retrograde axonal transport.
J Neurosci Methods, doi:10.1016/j.jneumeth.2006.10.010.
2006

Iliev A.I., Ganesan S., Bunt G., Wouters F.S.
Removal of pattern-breaking sequences in microtubule binding repeats produces instantaneous tau aggregation and toxicity.
J Biol Chem., 281(48):37195-204.
2006

Lotz M., Ebert S., Esselmann H., Iliev A.I., Prinz M., Wiazewicz N., Wiltfang J., Gerber J., Nau R.
Amyloid beta peptide 140 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures.
J Neurochem., 94(2):289-98.
2005

Stagi M., Dittrich P.S., Frank N., Iliev A.I., Schwille P., Neumann H. Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide.
J Neurosci., 25(2):352-62.
2005

Iliev A.I., Stringaris A.K., Nau R., Neumann H.
Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9).
FASEB J., 18(2):412-4.
2004

Iliev A., Traykov V., Stoykov I., Yakimova K.
Estradiol inhibits astrocytic GFAP-expression in an animal model of neuroinflammation.
Methods Find Exp Clin Pharmacol., 23(1): 29-35.
2001

Iliev A., Traykov V., Mantchev G., Stoykov I., Prodanov D., Yakimova K., Krushkov I.
A Post-ischaemic single administration galanthamine, a cholinesterase inhibitor, improves learning ability in rats.
J Pharm Pharmacol; 52: 1151-1156
2000

Iliev A., Traykov V., Prodanov D., Mantchev G., Yakimova K., Krushkov I., Boyadjieva N.
Effect of the acetylcholinesterase inhibitor galanthamine on learning and memory in prolonged alcohol intake rat model of acetylcholine deficit.
Methods Find Exp Clin Pharmacol., 21(4):297-301.
1999

Prodanov D., Mantchev G., Iliev A., Traykov V., Yakimova K., Kaneva R., Krushkov I.
Effects of dexamethasone in rat neonatal model of axotomy-induced motoneuronal cell death.
Arch Physiol Biochem., 106(5):355-361.
1998